Students are challenged to think as biomedical engineers and brainstorm ways to administer medication to a patient who is unable to swallow. They learn about the advantages and disadvantages of current drug delivery methods—oral, injection, topical, inhalation and suppository—and pharmaceutical design considerations, including toxicity, efficacy, size, solubility/bioavailability and drug release duration. They apply their prior knowledge about human anatomy, the circulatory system, polymers, crystals and stoichiometry to real-world biomedical applications. A Microsoft® PowerPoint® presentation and worksheets are provided. This lesson prepares students for the associated activity in which they create and test large-size drug encapsulation prototypes to provide the desired delayed release and duration timing.

Students operate mock 3D bioprinters in order to print tissue constructs of bone, muscle and skin for a fictitious trauma patient, Bill. The model bioprinters are made from ordinary materials— cardboard, dowels, wood, spools, duct tape, zip ties and glue (constructed by the teacher or the students)—and use squeeze bags of icing to lay down tissue layers. Student groups apply what they learned about biological tissue composition and tissue engineering in the associated lesson to design and fabricate model replacement tissues. They tangibly learn about the technical aspects and challenges of 3D bioprinting technology, as well as great detail about the complex cellular composition of tissues. At activity end, teams present their prototype designs to the class.

Students set up and run the experiments they designed in the Population Growth in Yeasts associated lesson, using simple yeast-molasses cultures in test tubes. Population growth is indicated by the amount of respiration occurring in the cultures, which in turn is indicated by the growth of carbon dioxide bubbles trapped within the culture tubes. Using this method, students test for a variety of environmental influences, such as temperature, food supply and pH.

This interactive simulation of human homeostasis provides students the opportunity to explore how our body maintains a stable internal environment in spite of of the outside conditions, within certain limits. This simulation allows students to investigate a phenomenon that may in real life, be dangerous to humans. Students are asked to regulate the internal body temperature of an individual using clothing, exercise, and perspiration. A four- page exploration sheet guides students through the simulation, including a short prior knowledge piece providing information on how to use the simulation and introductory questions. Two separate activities are included: one that helps students understand the how each external factor affects initial body temperature and another that allows students to explore effects on body temperature after one hour. In the second portion of the interactive simulation students try to maintain a stable body temperature when the factors are changed. Students choose the factors of exercise level, sweat level, body position, clothing, and nutrients in terms of both water and food to maintain homeostasis. The simulation generates data tables and graphing during specific time intervals of outside temperature and body temperature. Students may also alter the outside temperature as part of the simulation. Students adjust the exercise level, amount of clothing, and sweating levels. Water level, sugar level, and fatigue level are influenced by the students’ choices and are illustrated by bar graphs and line graphs. This simulation can provide an introduction to a lesson or unit that explores how body systems interact. This simulation provides a good foundation for continued study of how the body systems interact and would be an excellent starting point for a lesson or unit on this concept. This interactive simulation provides students with a strong introduction to how body systems interact as the simulation illustrates how to maintain body temperature, sugar level and fatigue level and students are made aware of the consequences of not maintaining those levels. The importance of water and food are also emphasized. Students can rerun the simulation making different choices to determine the effects on homeostasis. Student exploration sheets provide guides for different runs with students setting their own parameters for the runs and drawing conclusions from the resulting changes. Teachers can view student assessment responses by assigning the simulation to a class created within the ExploreLearning site. Access to the teachers guide is provided with the free 30 day access and is helpful and complete. Vocabulary of dehydration, heat stroke, homeostasis, hypothermia, and involuntary, voluntary and thermoregulation are explained in detail in the accompanying teacher’s vocabulary guide.

This Instructor’s Guide contains the brief outlines of Chapters 12-21 as found in Concepts of Biology, though some underwent revision. Also, instructors will find detailed outlines of the text for use in lecturing, as well as structured outlines that may be used by students to take notes while reading the chapter or during lecture. All outlines are derived from the OpenStax text. Additionally, study guides that contain a variety of questions are provided for students.

Introduction to Ecology is an open course remix of the OpenStax Biology open textbook. The remix includes a modular revision of parts of the text with supplemental questions added.

This set of lecture materials, laboratory notes, and activities are ancillary materials created for use with OpenStax Microbiology. The materials were created under a Round Nine Textbook Transformation Grant.

Topics covered include:

The Cell
Prokaryotes
Eukaryotes
Acellular Pathogens
Microbial Metabolism
Microbial Growth
Biochemistry of the Bacterial Genome
Microbial Genetics
Microbial Growth
Antimicrobial Drugs
Pathogenicity
Epidemiology
Immune System

Students learn about the current applications and limitations of 3D bioprinting, as well as its amazing future potential. This lesson, and its fun associated activity, provides a unique way to review and explore concepts such as differing cell functions, multicellular organism complexity, and engineering design steps. As introduced through a PowerPoint® presentation, students learn about three different types of bioprinters, with a focus on the extrusion model. Then they learn the basics of tissue engineering and the steps to design printed tissues. This background information prepares students to conduct the associated activity in which they use mock-3D bioprinters composed of a desktop setup that uses bags of icing to “bioprint” replacement skin, bone and muscle for a fictitious trauma patient, Bill. A pre/post-quiz is also provided.

Students design and conduct simple experiments using elodea (aquatic plant sold in pet stores) and Bromthymol blue to determine whether plants consume or release carbon dioxide in the process of photosynthesis. Students will record their data which will be used to conclude whether carbon dioxide was consumed or released by the elodea. Through class discussion of student data, students will learn that carbon dioxide was consumed during photosynthesis.

Students work in pairs to compare five aspects of an organism that reproduces sexually, asexually, or both sexually and asexually. The activity comes with a chart for the students to fill out and with information sheets on twelve organisms. As a class, students share their comparisons and generate a list of general characteristics for each mode of reproduction and then discuss the advantages and disadvantages of both. Included in the discussion are reproductive mechanisms and genetic variation.

Using ordinary household materials, student “biomedical engineering” teams design prototype models that demonstrate semipermeability under the hypothetical scenario that they are creating a teaching tool for medical students. Working within material constraints, each model consists of two layers of a medium separated by material acting as the membrane. The competing groups must each demonstrate how water (or another substance) passes through the first layer of the medium, through the membrane, and into the second layer of the medium. After a few test/evaluate/redesign cycles, teams present their best prototypes to the rest of the class. Then student teams collaborate as a class to create one optimal design that reflects what they learned from the group design successes and failures. A pre/post-quiz, worksheet and rubric are provided.

Through two lessons and five activities, students explore the structure and function of cell membranes. Specific transport functions, including active and passive transport, are presented. In the legacy cycle tradition, students are motivated with a Grand Challenge question. As they study the ingress and egress of particles through membranes, students learn about quantum dots and biotechnology through the concept of intracellular engineering.

This Java-based NetLogo model allows students to investigate the chemical and energy inputs and outputs of photosynthesis through an interactive simulation. The simulation is a visual, conceptual model of photosynthesis and does not generate quantitative data. The central concept in the model is the role of chlorophyll in capturing light energy, and this concept is presented without delving into the biochemical details of the photosynthetic reactions. This allows students to focus on the core idea that photosynthesis transforms light energy into chemical energy. Along with exploring the basic process of photosynthesis, students can investigate the effects of light intensity, the day-night cycle (assuming the most common C3 photosynthetic pathway), CO2 concentration, and water availability on the rate of sugar production during photosynthesis. The model highlights the cycling within the chloroplasts between excited and unexcited states as energy is captured and released by chlorophyll. The lesson is written as an introductory learning experience, beginning with the question: What is needed for photosynthesis in a leaf, and what is produced? This resource is best suited as one in a series of learning experiences that either reinforce or extend the concepts addressed here. The model is embedded within an electronic form that provides instructions and guiding questions. Teachers and students should note that the electronic form does not save user data. An important limitation is that the model relies heavily on students’ visual perception, and this may pose a barrier for some students.

In this lesson, students will extend their knowledge of matter and energy cycles in an organism to engineering life cycle assessment of a product. Students will learn about product life cycle assessment and the flow of energy through the cycle, comparing it to the flow of nutrients and energy in the life cycle of an organism.

Insert channels in a membrane and see what happens. See how different types of channels allow particles to move through the membrane.

Insert channels in a membrane and see what happens. See how different types of channels allow particles to move through the membrane.

This Protein Purification video lesson is intended to give students some insight into the process and tools that scientists and engineers use to explore proteins. It is designed to extend the knowledge of students who are already somewhat sophisticated and who have a good understanding of basic biology. The question that motivates this lesson is, ''what makes two cell types different?'' and this question is posed in several ways. Such scientific reasoning raises the experimental question: how could you study just a subset of specialized proteins that distinguish one cell type from another? Two techniques useful in this regard are considered in the lesson.

Microbiology covers the scope and sequence requirements for a single-semester microbiology course for non-majors. The book presents the core concepts of microbiology with a focus on applications for careers in allied health. The pedagogical features of the text make the material interesting and accessible while maintaining the career-application focus and scientific rigor inherent in the subject matter. Microbiology’s art program enhances students’ understanding of concepts through clear and effective illustrations, diagrams, and photographs.

As a group of organisms that are too small to see and best known for being agents of disease and death, microbes are not always appreciated for the numerous supportive and positive contributions they make to the living world. Designed to support a course in microbiology, Microbiology: A Laboratory Experience permits a glimpse into both the good and the bad in the microscopic world. The laboratory experiences are designed to engage and support student interest in microbiology as a topic, field of study, and career.

This text provides a series of laboratory exercises compatible with a one-semester undergraduate microbiology or bacteriology course with a three- or four-hour lab period that meets once or twice a week. The design of the lab manual conforms to the American Society for Microbiology curriculum guidelines and takes a ground-up approach — beginning with an introduction to biosafety and containment practices and how to work with biological hazards. From there the course moves to basic but essential microscopy skills, aseptic technique and culture methods, and builds to include more advanced lab techniques. The exercises incorporate a semester-long investigative laboratory project designed to promote the sense of discovery and encourage student engagement. The curriculum is rigorous but manageable for a single semester and incorporates best practices in biology education.

Microbiology for Allied Health Students is designed to cover the scope and sequence requirements for the single semester Microbiology course for non-majors and allied health students. The book presents the core concepts of microbiology with a focus on applications for careers in allied health. The pedagogical features of Microbiology for Allied Health Students make the material interesting and accessible to students while maintaining the career-application focus and scientific rigor inherent in the subject matter.

The scope and sequence of Microbiology for Allied Health Students has been developed and vetted with input from numerous instructors at institutions across the U.S. It is designed to meet the needs of most microbiology courses allied health students.

With these objectives in mind, the content of this textbook has been arranged in a logical progression from fundamental to more advanced concepts. The opening chapters present an overview of the discipline, with individual chapters focusing on cellular biology as well as each of the different types of microorganisms and the various means by which we can control and combat microbial growth. The focus turns to microbial pathogenicity, emphasizing how interactions between microbes and the human immune system contribute to human health and disease. The last several chapters of the text provide a survey of medical microbiology, presenting the characteristics of microbial diseases organized by body system.